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Medchemexpress LLC CHS-828 (GMX1778) | 200484-11-3 | 99.3% | 371.86 | 25 MG
Supplier: Medchemexpress LLC 25MGHY10079
CHS-828 (GMX1778) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with an IC50 of less than 25 nM. It decreases cellular NAD+ levels, exerting a cytotoxic and potent anticancer effect. The compound increases intracellular reactive oxygen species (ROS) in cancer cells by elevating superoxide levels without inducing ROS in normal cells. Its ROS-inducing effects can be modulated by nicotinic acid in a NAPRT1-dependent manner.
- Competitive inhibitor of NAMPT (IC50 < 25 nM).
- Decreases cellular NAD+ levels.
- Demonstrates potent anticancer activity.
- Increases intracellular ROS in cancer cells.
- Does not induce ROS in normal cells.
- ROS induction can be reduced by nicotinic acid.
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