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Abcam CHZ868, 25MG
Supplier: Abcam AB28706525MG
MW 423.4 Da, Purity >=98%. CHZ868 is a potent and selective type II JAK2 inhibitor (IC₅₀ = 110 nM). JAK2 and MPL mutant cell lines are sensitive to CHZ868, including type I JAK inhibitor persistent cells. CHZ868 displays significant activity in murine MPN models and induces reductions in mutant allele burden not observed with type I JAK inhibitors.
The product is subject to the following: Abcam Restricted Use Statement
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