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Apexbio Technology LLC Cilengitide 188968-51-6 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A86605.1

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Cilengitide (CAS 188968-51-6) is a cyclic RGD pentapeptide [Arg-Gly-Asp-DPhe-(NMeVal)] that acts as an inhibitor of integrins v 3 and v 5 These integrins are transmembrane receptors mediating cellular processes such as adhesion migration angiogenesis and invasion Cilengitide binds directly to v 3 integrin receptors inhibiting integrin-mediated activities with an IC50 of 250 nM In in vitro assays cilengitide dose-dependently reduces proliferation and adhesion of endothelial progenitor cells In vivo studies showed that cilengitide administration significantly lowered osteolytic lesion formation and soft tissue involvement in metastatic MDA-MB-231 tumor models

Catalog No. 50-000-61728


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