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Medchemexpress LLC Cilobradine hydrochloride | 186097-54-1 | 99.7% | 519.07 | 25 MG
Supplier: Medchemexpress LLC 25MGHY18940A
Cilobradine hydrochloride is an HCN channel blocker that induces cardiac pacemaker currents and produces antidepressant effects. It works by blocking HCN channel currents in cells and can reverse depressive-like behavior in vivo, with effects lasting for about two weeks.
- Induces cardiac pacemaker currents
- Produces antidepressant effects
- Blocks HCN channel currents in HEK293 cells
- Not isoform-specific in steady-state inhibition of different HCN isoforms
- Can prolong the latency of the a-wave or b-wave of the rat electroretinogram (ERG)
- Can reverse depressive-like behavior
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