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Medchemexpress LLC Cilobradine hydrochloride | 186097-54-1 | 99.7% | 519.07 | 5 MG
SDP

Catalog No. 5000385104
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Cilobradine hydrochloride is a HCN channel blocker that induces cardiac pacemaker currents and produces antidepressant effects. It is for research use only and not sold to patients.

  • HCN channel blocker
  • Induces cardiac pacemaker currents
  • Produces antidepressant effects
  • Induces a use-dependent blockade of cardiac pacemaker current in rabbit sino-atrial cells (1 μM)
  • Blocks HCN channel currents in HEK293 cells expressing human HCN1, HCN2, HCN3, and HCN4 channels in a dose- and treatment-dependent manner
  • Can prolong the latency of the a-wave or b-wave of the rat electroretinogram (ERG) (4-40 mg/kg; s.c.)
  • Can reverse depressive-like behavior in male C57BL/6J mice, with effects lasting about two weeks (intracerebroventricular injection 0.6 μg; intraperitoneal injection 20 mg/kg)

Catalog No. 50-003-85104 Supplier Medchemexpress LLC Supplier No. HY18940A5MG
May include imposed supplier surcharges.
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Cilobradine hydrochloride is a HCN channel blocker that induces cardiac pacemaker currents and produces antidepressant effects. It is for research use only and not sold to patients.

  • HCN channel blocker
  • Induces cardiac pacemaker currents
  • Produces antidepressant effects
  • Induces a use-dependent blockade of cardiac pacemaker current in rabbit sino-atrial cells (1 μM)
  • Blocks HCN channel currents in HEK293 cells expressing human HCN1, HCN2, HCN3, and HCN4 channels in a dose- and treatment-dependent manner
  • Can prolong the latency of the a-wave or b-wave of the rat electroretinogram (ERG) (4-40 mg/kg; s.c.)
  • Can reverse depressive-like behavior in male C57BL/6J mice, with effects lasting about two weeks (intracerebroventricular injection 0.6 μg; intraperitoneal injection 20 mg/kg)

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