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Medchemexpress LLC Cilobradine hydrochloride | 186097-54-1 | 99.7% | 519.07 | 50 MG
Supplier: Medchemexpress LLC HY18940A50MG
Cilobradine hydrochloride is a HCN channel blocker that induces cardiac pacemaker currents and produces antidepressant effects. It is intended for research use only.
- Induces a use-dependent blockade of cardiac pacemaker current in rabbit sino-atrial cells.
- Blocks HCN channel currents in HEK293 cells expressing human HCN1, HCN2, HCN3, and HCN4 channels in a dose- and treatment-dependent manner, and its steady-state inhibition of different HCN isoforms is not isoform-specific.
- Can prolong the latency of the a-wave or b-wave of the rat electroretinogram (ERG).
- Produces a dose-dependent waveform change after the b-wave at a specific light stimulus brightness.
- Can reverse depressive-like behavior, and the effect lasts for about two weeks.
- Increases time in social interaction and reduces time in the corner zone.
- Increases sucrose preference and reduces immobility time in the forced swim test.
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