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Apexbio Technology LLC Cinacalcet HCl 364782-34-3 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC B14235.1

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Cinacalcet HCl (CAS 364782-34-3) is a second-generation calcimimetic that acts as a potent allosteric modulator of the calcium-sensing receptor (CaSR) By enhancing the sensitivity of CaSR to extracellular calcium Cinacalcet HCl suppresses parathyroid hormone (PTH) secretion with an EC50 of 2 8 M reported in in vitro assays In preclinical models such as Rice H-500 tumor-bearing mice oral administration of Cinacalcet HCl significantly reduces blood ionized calcium total serum calcium and PTH-related peptide (PTHrP) levels Its ability to modulate mineral metabolism supports its use in research on disorders involving PTH dysregulation including secondary hyperparathyroidism and related mineral imbalances

Catalog No. 50-000-91218


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