Thermo Scientific Chemicals Cinchonidine, 98.5-101%

Description

Cinchonidine, CAS # 485-71-2, is a naturally occurring alkaloid that may be used in asymmetric synthesis and exhibits anti-malarial activity | CAS: 485-71-2 | C19H22N2O | 294.40 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Cinchonidine is an alkaloid naturally occurring in the bark of Cinchona strubs that has activity against Plasmodium spp
• Cinchonidine is a diastereoisomer of cinchonine and can be used to promote chirality in asymmetric or enantioselective synthesis of organic compounds

Applications

• Cinchonidine has been used as a starting material in the synthesis of anti-malarial cinchona alkaloid conjugates
• Has been shown to potently induce γ-globin mRNA and fetal hemoglobin in erythroid progenitor cells and may be useful in preclinical studies of β-thalassemia

Specifications

Chemical Identifiers

• CAS: 485-71-2
• Molecular Formula: C19H22N2O
• Molecular Weight (g/mol): 294.40
• MDL Number: MFCD00006783
• InChI Key: KMPWYEUPVWOPIM-UHFFFAOYNA-N
• Synonym: cinchonidine
• PubChem CID: 45358337
• IUPAC Name: [(2R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-quinolin-4-ylmethanol
• SMILES: OC(C1CC2CCN1CC2C=C)C1=C2C=CC=CC2=NC=C1

• Melting Point: 200.0°C to 203.0°C
• Color: White to Cream
• Loss on Drying: 1% max. (105°C)
• Infrared Spectrum: Authentic
• Assay Percent Range: 98.5-101%
• Packaging: Glass bottle
• Quantity: 25 g
• Beilstein: 23, 420
• Merck Index: 15, 2289
• Specific Rotation: − 115.00
• Solubility Information: Solubility in water: insoluble. Other solubilities: soluble in alcohol and chloroform
• Formula Weight: 294.39
• Percent Purity: 98.5-101%
• Physical Form: Crystalline Powder
• Chemical Name or Material: Cinchonidine, 98.5-101%

Safety and Handling

Hazard Category	GHS Signal Word: Warning
Hazard Statement	GHS H Statement Harmful if swallowed. May cause an allergic skin reaction.
Precautionary Statement	GHS P Statement Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
EINECSNumber	207-622-3
RTECSNumber	GD2975000
TSCA	TSCA

SDS

RUO – Research Use Only