Medchemexpress LLC Cinnabarinic acid | 606-59-7 | 99.9% | 300.22 | 10 MG

Supplier:  Medchemexpress LLC HYW01141710MG

Cinnabarinic acid is identified as a specific orthosteric agonist of mGlu4, acting through interaction with residues in the glutamate binding pocket without activity at other mGlu receptors. It is an endogenous metabolite of the kynurenine pathway of tryptophan and is known to induce cell apoptosis.

• Specific orthosteric agonist of mGlu4.
• Acts via interaction with residues in the glutamate binding pocket of mGlu4.
• Shows no activity at other mGlu receptors (mGlu1, mGlu2, mGlu5, mGlu6, mGlu7, mGlu8).
• Endogenous metabolite of the kynurenine pathway of tryptophan.
• Induces cell apoptosis.
• Acts as a partial agonist of mGlu4 receptors.
• Increases [3H]InsP formation by approximately 35% at 100 μM.
• Reduces cAMP formation in a concentration-dependent manner.
• Effective at 30 μM in inhibiting cAMP formation in cultured cerebellar granule cells.

Catalog No. 50-003-66573