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Cayman Chemical CINOBUFAGIN 10MG
Supplier: Cayman Chemical 1984410 MG
A cardiotonic steroid that has diverse biological activities; inhibits Na+/K+-ATPase activity in guinea pig heart ventricular muscle homogenates at 0.3 μM; is cytotoxic to HCT116 cells in vitro (IC50s = <50 ng/ml at 48- and 72-hour time points) and induces apoptosis; reduces tumor growth in an HCT116 mouse xenograft model at 10 mg/kg; inhibits LPS-induced expression of MHC class II, CD80, and CD86 and release of IL-6, IL-8, TNF-α, and IL-10 in human monocyte-derived dendritic cells at 1 μg/ml; increases expression of hBD2 and hBD3 in dendritic cells; exhibits antinociceptive effects in mice
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