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Cayman Chemical CInserInhydrochlorIde 10mg

Supplier: Cayman Chemical 3072910 MG

An orally bioavailable inhibitor of ASK1 (IC50 14 nM) selective for ASK1 over ASK2 (IC50 510 nM) as well as MEKK1 TAK-1 IKKB ERK1 JNK1 p38a GSK3B PKC and B-RAF (IC50s 10000 nM for all) inhibits streptozotocin-induced increases in JNK and p38 phosphorylation in INS-1 pancreatic B cells in a concentration-dependent manner
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