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Medchemexpress LLC Ciproxifan maleate | 184025-19-2 | C20H22N2O6 | 1 ML
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Supplier:  Medchemexpress LLC HY1528910MM/1ML

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Ciproxifan maleate is a potent, selective, orally bioavailable, and competitive antagonist of the histamine H3-receptor, with an IC50 of 9.2 nM. It shows low apparent affinity at other receptor subtypes and can be used for the research of aging disorders and Alzheimer's disease.

  • Inhibits [3H]HA release from synaptosomes of rat cerebral cortex (Ki: 0.5 nM).
  • Inhibits binding of [125I]iodoproxyfan with rat striatal membranes (Ki: 0.7 nM).
  • Increases t-MeHA level in mouse brain (ED50: 0.14 mg/kg).
  • Improves accuracy of responding in five-choice tasks in rats.
  • Induces neocortical electroencephalogram activation and waking state in cats.
  • Decreases H3-receptor ligand concentration in serum in mice.
  • Exhibits oral bioavailability (F=62%) and maximal concentration (Cmax=420 nM) in mice.

Catalog No. 50-003-73797


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