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Cayman Chemical CItreoIndole 2.5mg
Supplier: Cayman Chemical 220692.5 MG
A potent and selective SIRT2 inhibitor (IC50s 0 028 98 200 and 200 M for SIRT2 SIRT1 SIRT3 and SIRT5-7 respectively) inhibits acetyl-H3K9 peptide and NAD binding to SIRT2 and promotes c-Myc degradation in a dose-dependent manner exhibits selective cytotoxicity (IC50s 8 4-36 8 and 50 M for cancerous and non-cancerous cell lines respectively) decreases tumor volume and increases areas of necrosis in an MDA-MB-231 mouse breast cancer xenograft model increases tumor-free survival time in a MMTV-PyMT mouse mammary tumor model
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