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Apexbio Technology LLC CJ-42794(Synonyms: CJ42794, CJ 42794, CJ-42794, EP4 antagonist CJ-42794, CAS 847728-01-2), 250mg, CAS: 847728-01-2.
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Supplier:  Apexbio Technology LLC C4037250

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CJ-42794 (CAS 847728-01-2) is a potent and selective antagonist targeting prostaglandin E receptor subtype 4 (EP4) It exhibits high affinity for EP4 receptors (Ki 3 16 nM) with significantly lower potency at EP2 receptors (Ki 631 nM) and negligible affinity for EP1 or EP3 By blocking EP4-mediated signaling CJ-42794 prevents prostaglandin E2-induced intracellular cAMP elevation thereby reversing PGE2-dependent inhibition of inflammatory responses such as lipopolysaccharide-induced TNF- secretion In animal models administration of CJ-42794 delays gastric ulcer healing through suppression of VEGF expression and angiogenesis This compound serves as a valuable tool for investigating EP4-associated physiological and pathological processes

Catalog No. 50-000-61178


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