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Medchemexpress LLC CK-666 | 442633-00-3 | 99.95% | 296.34 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY1692610MM/1ML

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CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor with an IC50 of 12 μM. It binds to the Arp2/3 complex, stabilizing its inactive state and blocking the movement of the Arp2 and Arp3 subunits into the activated filament-like conformation.

  • Cell-permeable
  • Arp2/3 complex inhibitor
  • Stabilizes the inactive state of the Arp2/3 complex
  • Blocks movement of Arp2 and Arp3 subunits into activated filament-like conformation
  • Significantly reduces filopodia on cell surface of treated trabecular meshwork (TM) cells.
  • Reduces uptake of S-EMs by VSMCs.
  • Inhibits S-EMs-induced proliferation of VSMCs.
  • Inhibits S-EMs-induced migration of VSMCs.
  • Reduces F-actin polymerization in E15.5 fetal mice.
  • Reduces F-actin/G-actin ratio in doxycycline-treated iPSC-derived neurons.

Catalog No. 50-003-90848


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