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Apexbio Technology LLC Clarithromycin 81103-11-9 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A43225.1
Clarithromycin is a macrolide antibiotic exhibiting inhibitory activity against the cytochrome P450 isoform CYP3A a critical enzyme involved in drug metabolism Through CYP3A inhibition clarithromycin elevates the plasma concentrations of substrates notably statins thereby potentially altering their pharmacokinetic profiles Clarithromycin demonstrates potent CYP3A inhibition with an approximate IC50 value of 32 M making it suitable for in vitro and in vivo research investigating drug-drug interaction mechanisms and pharmacokinetic studies involving CYP3A-dependent pathways Experimental applications include assessing clarithromycin s impact on hepatic CYP3A activity evaluating the metabolic stability of CYP substrates and characterizing interaction risks between concurrent medications that share CYP3A-mediated metabolic routes
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