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Medchemexpress LLC Clarithromycin | 81103-11-9 | 99.9% | 747.95 | 200 MG
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Supplier:  Medchemexpress LLC HY17508200MG

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Clarithromycin possesses a broad spectrum of antimicrobial activity. It inhibits CYP3A4-catalyzed triazolam alpha-hydroxylation with an IC50 (Ki) value of 56 (43) μM and significantly inhibits the hERG potassium current. Clarithromycin affects autophagic flux by impairing the signaling pathway linking hERG1 and PI3K, and can induce the formation of intracytoplasmic vacuoles and trigger apoptotic cell death in colorectal cancer (CRC) cells.

  • Broad spectrum of antimicrobial activity
  • Inhibits CYP3A4-catalyzed triazolam alpha-hydroxylation
  • Significantly inhibits the hERG potassium current
  • Affects autophagic flux by impairing the signaling pathway linking hERG1 and PI3K
  • Induces intracytoplasmic vacuole formation
  • Triggers apoptotic cell death in colorectal cancer cells

Catalog No. 50-003-86289


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