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Medchemexpress LLC Clarithromycin | 81103-11-9 | 99.93% | 747.95 | 500 MG
Supplier: Medchemexpress LLC HY17508500MG
Clarithromycin has a broad spectrum of antimicrobial activity. It inhibits CYP3A4-catalyzed triazolam alpha-hydroxylation with an IC50 (Ki) value of 56 (43) μM. It significantly inhibits the hERG potassium current and affects autophagic flux by impairing the signaling pathway linking hERG1 and PI3K. It has also shown activity against Mycobacterium avium complex infection in mice.
- Broad spectrum of antimicrobial activity
- Inhibits CYP3A4-catalyzed triazolam alpha-hydroxylation
- Significantly inhibits hERG potassium current
- Affects autophagic flux by impairing the signaling pathway linking hERG1 and PI3K
- Induces intracytoplasmic vacuoles in various cell lines
- Triggers apoptotic cell death in colorectal cancer cells
- Increases LC3-II/LC3-I ratio dose- and time-dependently
- Reduced organ cell counts in animal models of Mycobacterium avium infection
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