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Claudin 3 Polyclonal Antibody, Invitrogen™

Catalog No. 01673300
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01-673-300 1 mL
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Catalog No. 01-673-300 Supplier Thermo Scientific Supplier No. PA137469
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Description

Rabbit Polyclonal Antibody

This antibody is predicted to react with bovine, canine, mouse, porcine and rat based on sequence homology. Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is small intestine tissue.

Claudin 1-8 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact; made up of network of strands to act as a molecular gasket for preventing the leakage of ions, water etc. between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Claudin 3
Applications Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with 1% BSA and 0.1% sodium azide; pH 7.6
Gene CLDN3
Gene Accession No. O15551, Q63400, Q9Z0G9
Gene Alias AI182374; C7orf1; claudin 3; claudin-3; CLDN3; clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-R2; CPE-receptor 2; CPETR2; hRVP1; integral membrane protein claudin-3; mRVP1; Rat ventral prostate.1 protein; Rat ventral prostate.1 protein homolog; RVP1; tight junction protein; ventral prostate.1 protein; ventral prostate.1 protein homolog; ventral prostate.1-like protein
Gene Symbols CLDN3
Host Species Rabbit
Immunogen Synthetic peptide derived from the C-terminus of mouse Claudin-3
Purification Method Antigen affinity chromatography
Quantity 1 mL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12739, 1365, 374029, 431781, 65130
Target Species Chicken, Human, Mouse, Pig, Rat
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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