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ABclonal Technology CLEC4M Rabbit pAb
Supplier: ABclonal Technology A142681000UL
This gene encodes a C-type lectin involved in cell adhesion and pathogen recognition. It recognizes a range of pathogens, including tuberculosis mycobacteria, Ebola, HIV-1, influenza A, West Nile virus, and SARS-CoV. The protein has four domains: a C-terminal carbohydrate recognition domain, a flexible neck domain, a transmembrane region, and an N-terminal cytoplasmic domain for internalization. This gene is related to CD209 (DC-SIGN) but differs in viral recognition and expression. It is highly expressed in endothelial cells of the liver, lymph node, and placenta. Polymorphisms in the neck domain are linked to resistance to SARS infection.
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