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Medchemexpress LLC Clemizole hydrochloride | 1163-36-6 | 99.7% | 362.30 | 25 MG
Supplier: Medchemexpress LLC 25MGHY30234A
Clemizole hydrochloride is an H1 histamine receptor antagonist that has been shown to inhibit HCV replication. It is also an inhibitor of the TRPC5 channel. It effectively blocks TRPC5 currents and Ca2+ entry in the low micromolar range.
- IC50 for RNA binding by NS4B is 24 nM.
- EC50 for viral replication is 8 μM.
- Inhibits HCV RNA replication in cell culture by suppressing NS4B's RNA binding, with minimal toxicity to the host cell.
- Effectively blocks TRPC5 currents and Ca2+ entry in the low micromolar range (IC50=1.0-1.3 μM).
- Exhibits selectivity for TRPC5 over TRPC4β, TRPC3, and TRPC6.
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