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Medchemexpress LLC Clemizole hydrochloride | 1163-36-6 | 99.99% | 362.30 | 1 ML

Supplier: Medchemexpress LLC HY30234A10MM/1ML
Clemizole hydrochloride is an H1 histamine receptor antagonist that substantially inhibits HCV replication. It also acts as an inhibitor of the TRPC5 channel. The IC50 for RNA binding by NS4B is 24 nM, and its EC50 for viral replication is 8 μM.
- Inhibits HCV RNA replication
- Suppresses NS4B's RNA binding with low host cell toxicity
- Blocks TRPC5 currents and Ca2+ entry
- Exhibits selectivity for TRPC5 over TRPC4β, TRPC3, and TRPC6
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