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Medchemexpress LLC Clemizole hydrochloride | 1163-36-6 | 99.99% | 362.30 | 100 MG
Supplier: Medchemexpress LLC HY30234A100MG
Clemizole hydrochloride is an H1 histamine receptor antagonist that substantially inhibits HCV replication and is an inhibitor of the TRPC5 channel. It has an IC50 of 24 nM for RNA binding by NS4B and an EC50 of 8 μM for viral replication. For research use only.
- H1 histamine receptor antagonist.
- Substantially inhibits HCV replication.
- Inhibitor of TRPC5 channel.
- EC50 of 8 μM for viral replication.
- IC50 of 24 nM for RNA binding by NS4B.
- Inhibits HCV RNA replication in cell culture mediated by suppression of NS4B's RNA binding with little toxicity for the host cell.
- Efficiently blocks TRPC5 currents and Ca2+ entry in the low micromolar range (IC50=1.0-1.3 μM).
- Exhibits six-fold selectivity for TRPC5 over TRPC4β (IC50=6.4 μM) and almost 10-fold selectivity over TRPC3 (IC50=9.1 μM) and TRPC6 (IC50=11.3 μM).
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