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Apexbio Technology LLC Climbazole 38083-17-9 50mg
Supplier: Apexbio Technology LLC B170650
Climbazole (CAS 38083-17-9) is a small-molecule inhibitor targeting lanosterol 14 -demethylase (CYP51) an essential enzyme in fungal cell membrane synthesis It is designed to disrupt ergosterol biosynthesis thereby impairing fungal cell membrane integrity Climbazole exerts its biological activity primarily through inhibition of lanosterol 14 -demethylase In in vitro studies climbazole demonstrates broad-spectrum antifungal inhibitory activity with reported IC50 values ranging from approximately 0 2 M to 1 5 M depending on fungal species and experimental conditions Based on these pharmacological properties climbazole holds research potential in antifungal efficacy assessments mechanistic studies of fungal sterol metabolism and experimental models of dermatophytic and fungal scalp infections
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