Apexbio Technology LLC Clofarabine 123318-82-1 25mg

Supplier:  Apexbio Technology LLC A141225

Clofarabine (CAS 123318-82-1) is a nucleoside analogue that inhibits DNA synthesis by acting as a substrate for deoxycytidine kinase (dCK) a cytosolic enzyme involved in the DNA salvage pathway Intracellularly clofarabine undergoes phosphorylation to its triphosphate form which competes with dATP for DNA polymerase- and - and inhibits ribonucleotide reductase with an IC50 of 65 nM thereby decreasing dCTP and dATP pools Its monophosphate metabolite can be incorporated into DNA impeding strand elongation and repair Clofarabine is efficiently transported into cells via nucleoside transporters (hENT1 hENT2 hCNT2) and induces apoptosis through the release of cytochrome c APAF1 AIF and caspase-9 In vivo clofarabine exhibits pronounced antitumor activity in mouse xenograft models

Catalog No. 50-224-0492