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Clotrimazole

Catalog No. AAJ6389506
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Catalog No. AAJ6389506 Supplier Thermo Scientific Chemicals Supplier No. J6389506
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Description

Specific inhibitor of calcium-activated potassium channels | CAS: 23593-75-1 | C22H17ClN2 | 344.842 g/mol

Clotrimazole is an imidazole derivative and an antifungal compound and a CYP (cytochrome P450) inhibitor. Clotrimazole has been shown to block the intermediate-conductance, IK1 channels (Ca2+ activated K+ channels), in cells such as erythrocytes. In vitro studies of various yeast strains have demonstrated susceptibility to clotrimazole. Clotrimazole is an activator of MB67 and an inhibitor of CYP3A4 and CYP51A1.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Clotrimazole is an imidazole derivative and an antifungal compound and a CYP (cytochrome P450) inhibitor. Clotrimazole has been shown to block the intermediate-conductance, IK1 channels (Ca2+ activated K+ channels), in cells such as erythrocytes. In vitro studies of various yeast strains have demonstrated susceptibility to clotrimazole. Clotrimazole is an activator of MB67 and an inhibitor of CYP3A4 and CYP51A1.

Solubility
Soluble in chloroform, DMSO, DMF and alcohols

Notes
Store at room temperature. Incompatible with oxidizing agents.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 23593-75-1
Molecular Formula C22H17ClN2
Molecular Weight (g/mol) 344.842
MDL Number MFCD00057220
InChI Key VNFPBHJOKIVQEB-UHFFFAOYSA-N
Synonym 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole; 1-(o-Chlorotrityl)imidazole
PubChem CID 2812
ChEBI CHEBI:3764
IUPAC Name 1-[(2-chlorophenyl)-diphenylmethyl]imidazole
SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4

Specifications

Type Clotrimazole
Physical Form Powder
Melting Point 141°C to 149°C
Color White
Quantity 5 g
Merck Index 14,2417
Solubility Information Soluble in chloroform, DMSO, DMF and alcohols
Formula Weight 344.84
Chemical Name or Material Clotrimazole

Safety and Handling

Hazard Category H302-H315-H319
Hazard Statement GHS H Statement
H302-H315-H319
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
Precautionary Statement P264b-P270-P280-P301+P312-P302+P352-P305+P351+P338-P330-P332+P313-P362-P501c
EINECSNumber 245-764-8
RTECSNumber NI4377000
TSCA No
Recommended Storage Ambient temperatures
SDS

RUO – Research Use Only

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