Clotrimazole

Description

Specific inhibitor of calcium-activated potassium channels | CAS: 23593-75-1 | C22H17ClN2 | 344.842 g/mol

Clotrimazole is an imidazole derivative and an antifungal compound and a CYP (cytochrome P450) inhibitor. Clotrimazole has been shown to block the intermediate-conductance, IK1 channels (Ca2+ activated K+ channels), in cells such as erythrocytes. In vitro studies of various yeast strains have demonstrated susceptibility to clotrimazole. Clotrimazole is an activator of MB67 and an inhibitor of CYP3A4 and CYP51A1.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Clotrimazole is an imidazole derivative and an antifungal compound and a CYP (cytochrome P450) inhibitor. Clotrimazole has been shown to block the intermediate-conductance, IK1 channels (Ca2+ activated K+ channels), in cells such as erythrocytes. In vitro studies of various yeast strains have demonstrated susceptibility to clotrimazole. Clotrimazole is an activator of MB67 and an inhibitor of CYP3A4 and CYP51A1.

Solubility
Soluble in chloroform, DMSO, DMF and alcohols

Notes
Store at room temperature. Incompatible with oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 23593-75-1
• Molecular Formula: C22H17ClN2
• Molecular Weight (g/mol): 344.842
• MDL Number: MFCD00057220
• InChI Key: VNFPBHJOKIVQEB-UHFFFAOYSA-N
• Synonym: 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole; 1-(o-Chlorotrityl)imidazole
• PubChem CID: 2812
• ChEBI: CHEBI:3764
• IUPAC Name: 1-[(2-chlorophenyl)-diphenylmethyl]imidazole
• SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4

• Type: Clotrimazole
• Physical Form: Powder
• Melting Point: 141°C to 149°C
• Color: White
• Quantity: 25 g
• Merck Index: 14,2417
• Solubility Information: Soluble in chloroform, DMSO, DMF and alcohols
• Formula Weight: 344.84
• Chemical Name or Material: Clotrimazole

Safety and Handling

Hazard Category	H302-H315-H319
Hazard Statement	GHS H Statement H302-H315-H319 Harmful if swallowed. Causes skin irritation. Causes serious eye irritation.
Precautionary Statement	P264b-P270-P280-P301+P312-P302+P352-P305+P351+P338-P330-P332+P313-P362-P501c
EINECSNumber	245-764-8
RTECSNumber	NI4377000
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only