Thermo Scientific Chemicals Cloxacillin sodium salt monohydrate

Description

Cloxacillin sodium salt monohydrate, CAS # 7081-44-9, is a compound that targets gram-positive bacteria and shows antibacterial activity.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Cloxacillin sodium salt monohydrate is a chlorinated derivative of oxacillin that shows β-lactamase-resistant antibiotic activity

• This compound inhibits the last stage of bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), which results in cell lysis, that is mediated by bacterial cell wall autolytic enzymes

Applications

• Cloxacillin sodium salt monohydrate targets gram-positive bacteria, and is effective against staphylococci that produce β-lactamase

• It acts in vitro against both penicillin gram-resistant and gram-sensitive staphylococci, certain streptococci, and pneumococci

• This compound is commonly used in vivo and in vitro studies as AmpC β-lactamase inhibitor in combination with β-lactam antibiotics

Specifications

Chemical Identifiers

• CAS: 7081-44-9
• Molecular Formula: C19H19ClN3NaO6S
• Molecular Weight (g/mol): 475.876
• InChI Key: KCUWTKOTPIUBRI-VICXVTCVSA-M
• PubChem CID: 23675743
• ChEBI: CHEBI:34978
• IUPAC Name: sodium;(2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrate
• SMILES: CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].O.[Na+]

• Type: Cloxacillin Sodium Salt Monohydrate
• Infrared Spectrum: Authentic
• Water: 3.0 to 5.0%
• Quantity: 5 g
• Formula Weight: 475.88
• Percent Purity: ≥94% (HPLC)
• Chemical Name or Material: Cloxacillin sodium salt monohydrate

Safety and Handling

Hazard Category	Danger
Hazard Statement	GHS H Statement Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May cause an allergic skin reaction. May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Precautionary Statement	GHS P Statement IF ON SKIN: Wash with plenty of soap and water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician if you feel unwell. Wear protective gloves/protective clothing/eye protection/face protection.

RUO – Research Use Only