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Apexbio Technology LLC Clozapine 5786-21-0 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B22355.1
Clozapine (CAS 5786-21-0) is an atypical antipsychotic agent extensively studied for treating schizophrenia refractory to standard antipsychotics Clozapine exhibits high affinity binding to serotonin receptors 5-HT1c and 5-HT2 with reported pKi values of 8 07 and 7 63 respectively Additionally clozapine interacts with multiple dopamine receptor subtypes (D1-D5) displaying Ki values of 141 nM (D1) 80 nM (D2) 230 nM (D3) 89 nM (D4) and 250 nM (D5) Due to its distinctive receptor affinity profile clozapine serves as an important pharmacological tool in research on serotonin- and dopamine-mediated signaling mechanisms in psychiatric disorders
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