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Medchemexpress LLC Clozapine | 5786-21-0 | 99.8% | C18H19ClN4 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY14539100MG

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Clozapine is an antipsychotic used for the research of schizophrenia. It has high affinity for several neuroreceptors. Clozapine acts as a potent antagonist of dopamine D2 with a Ki of 75 nM. It also inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Ki values of 9.5 nM and 4 nM, respectively. Furthermore, Clozapine is a potent and selective agonist at the muscarinic M4 receptor (EC50 = 11 nM).

  • Antagonist of dopamine D2 and α2-adrenoceptor
  • Inhibits muscarinic M1 and serotonin 5HT2A receptors
  • Potent and selective agonist at muscarinic M4 receptor
  • Exhibits antipsychotic effects in mouse models
  • Inhibits human dopamine receptor D4.2 and D2L receptor

Catalog No. 50-003-54533


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