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Medchemexpress LLC Clozapine N-oxide | 34233-69-7 | MFCD00210190 | >99.8% | 342.82 | 25 MG
Supplier: Medchemexpress LLC 25MGHY17366A
Clozapine N-oxide is a major metabolite of Clozapine and acts as an agonist for human muscarinic designer receptors (DREADDs). It activates the DREADD receptors hM3Dq and hM4Di. Notably, Clozapine N-oxide does not cross the blood-brain barrier. Clozapine, its parent compound, is a potent dopamine antagonist and a potent and selective muscarinic M4 receptor agonist (EC50=11 nM).
- Activates the DREADD receptors hM3Dq and hM4Di.
- Does not cross the blood-brain barrier.
- Major metabolite of clozapine.
- Parent compound clozapine is a potent dopamine antagonist.
- Parent compound clozapine is a selective muscarinic M4 receptor agonist.
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