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Medchemexpress LLC Clozapine N-oxide dihydrochloride | 2250025-93-3 | 99.7% | 415.74 | 5 MG
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Supplier:  Medchemexpress LLC HY17366A5MG

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Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and acts as an agonist for human muscarinic designer receptors (DREADDs). It activates the DREADD receptors hM3Dq and hM4Di. While it cannot cross the blood-brain barrier, its parent compound, Clozapine, is a potent dopamine antagonist and a selective muscarinic M4 receptor agonist (EC50=11 nM).

  • Activates hM3Dq and hM4Di DREADD receptors.
  • Does not cross the blood-brain barrier.
  • Undergoes reverse-metabolism to clozapine.
  • Exhibits long biological effects (6-10 h) in mice.

Catalog No. 50-003-84470


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