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Medchemexpress LLC CMPD1 | 41179-33-3 | 99.86% | 349.40 | 50 MG
SDP

Catalog No. 5000346533
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CMPD1 is a selective and non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor with an apparent Ki (Kiapp) of 330 nM. It is for research use only and not sold to patients. This compound does not inhibit p38 MAPK-mediated phosphorylation of other two substrates, MBP and ATF2. It induces mitotic arrest and apoptosis in U87 cells, and inhibits tubulin polymerisation in glioblastoma cells.

  • Antiproliferative activity against human A-172 cells assessed as cell growth inhibition (EC50 0.6 μM).
  • Antiproliferative activity against human U-251 cells assessed as cell growth inhibition (EC50 0.6 μM).
  • Antiproliferative activity against human U-87MG ATCC cells assessed as cell growth inhibition (EC50 0.6 μM).
  • Inhibition of tubulin polymerization in human U87 cells assessed as decrease in cell viability after 72 hrs by Alamar blue assay (EC50 < 1 μM).

Catalog No. 50-003-46533 Supplier Medchemexpress LLC Supplier No. HY10864350MG
May include imposed supplier surcharges.
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CMPD1 is a selective and non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor with an apparent Ki (Kiapp) of 330 nM. It is for research use only and not sold to patients. This compound does not inhibit p38 MAPK-mediated phosphorylation of other two substrates, MBP and ATF2. It induces mitotic arrest and apoptosis in U87 cells, and inhibits tubulin polymerisation in glioblastoma cells.

  • Antiproliferative activity against human A-172 cells assessed as cell growth inhibition (EC50 0.6 μM).
  • Antiproliferative activity against human U-251 cells assessed as cell growth inhibition (EC50 0.6 μM).
  • Antiproliferative activity against human U-87MG ATCC cells assessed as cell growth inhibition (EC50 0.6 μM).
  • Inhibition of tubulin polymerization in human U87 cells assessed as decrease in cell viability after 72 hrs by Alamar blue assay (EC50 < 1 μM).

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