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Apexbio Technology LLC CNQX 115066-14-3 10mg
Supplier: Apexbio Technology LLC B622210
CNQX (CAS 115066-14-3) is a selective and competitive antagonist of AMPA and kainate subtype ionotropic glutamate receptors In hippocampal slice preparations superfusion with CNQX at concentrations of 2 5 M reversibly inhibits excitatory post-synaptic potentials mediated by Schaffer collaterals and mossy fibers while preserving both fast and slow GABAergic inhibitory responses In behavioral studies bilateral infusion of CNQX into the amygdala or dorsal hippocampus prior to testing partially suppresses the expression of conditioned avoidance responses with complete blockade observed at specific doses CNQX is widely utilized to dissect excitatory synaptic transmission and investigate non-NMDA receptor functions in neurophysiological and behavioral research
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