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Medchemexpress LLC CNQX disodium | 479347-85-8 | C9H2N4Na2O4 | 25 MG
Supplier: Medchemexpress LLC 25MGHY15066A
CNQX disodium is a potent and competitive antagonist for AMPA/kainate receptors, with IC50s of 0.3 μM and 1.5 μM respectively. It also acts as a competitive non-NMDA receptor antagonist and has been shown to block the expression of fear-potentiated startle in rats.
- Potent and competitive AMPA/kainate receptor antagonist
- IC50 values of 0.3 μM for AMPA and 1.5 μM for kainate receptors
- Competitive non-NMDA receptor antagonist
- Demonstrated activity in in vitro studies, including reversible blockade of Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP)
- Demonstrated activity in in vivo studies, showing decreased cocaine responses and partial blockade of stepdown inhibitory avoidance
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