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Apexbio Technology LLC CNQX disodium salt 479347-85-8 50mg
Supplier: Apexbio Technology LLC B656750
CNQX disodium salt (CAS 479347-85-8) is a competitive antagonist of non-NMDA glutamate receptors specifically targeting AMPA and kainate subtypes with IC50 values of 0 3 M and 1 5 M respectively By inhibiting these receptors CNQX blocks fast excitatory synaptic transmission in the central nervous system In thalamic reticular neurons CNQX induces sustained depolarization while showing minimal effect on ventrobasal neurons In vivo administration of CNQX in rats reduces capsaicin-induced c-fos expression in the trigeminal nucleus caudalis without influencing other reticular regions CNQX is widely used to delineate non-NMDA receptor functions in neurophysiological and behavioral studies
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