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Apexbio Technology LLC Cobicistat (GS-9350) 1004316-88-4 200mg
Supplier: Apexbio Technology LLC A4313200
Cobicistat (GS-9350) is a selective inhibitor of cytochrome P450 3A enzyme (CYP3A) showing inhibitory activity with an IC50 ranging from 0 03 to 0 285 M in vitro It lacks intrinsic anti-HIV activity but serves primarily as a pharmacokinetic enhancer used in combination therapy to increase the systemic exposure of HIV-1 protease inhibitors such as atazanavir and darunavir Clinically cobicistat is administered orally to HIV-1-infected adults facilitating optimized dosing regimens Due to its selective CYP3A inhibitory mechanism cobicistat is employed in pharmacokinetic studies and drug-drug interaction investigations related to HIV treatments
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