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Apexbio Technology LLC Cobimetinib 934660-93-2 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A33215.1

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Cobimetinib (CAS 934660-93-2) is a selective small molecule inhibitor targeting mitogen-activated protein kinase kinase (MEK) MEK functions as a kinase that specifically phosphorylates serine/threonine and tyrosine residues playing a critical role in the MAPK signaling cascade and modulating cell proliferation survival migration differentiation and angiogenesis Cobimetinib effectively inhibits MEK with an IC50 value of 0 9 nM demonstrating potent activity in various experimental cancer models including breast cancer cells harboring KRAS and B-RAF mutations In xenograft mouse models it exhibits dose-dependent tumor growth suppression and sustained inhibition of ERK phosphorylation Cobimetinib is currently evaluated in phase I clinical trials as an anticancer therapeutic candidate

Catalog No. 50-000-64393


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