Thermo Scientific Chemicals Colchicine, 97%

Description

Colchicine, 7alphah-colchicine, CAS # 64-86-8, is a laboratory grade formulation of the anti-inflammatory plant alkaloid drug.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

• Colchicine (7alphah-colchicine) is an alkaloid found in Colchicum autumnale that has been shown to have anti-gout and anti-inflammatory properties
• Colchicine binds tubulin and prevents the migration of immune cells, reducing inflammation

Applications

• Colchicine is an anti-mitotic; may be used in the study of cell proliferation and migration
• Intended for in vivo and in vitro research applications
• For research use only, not intended to treat disease

Specifications

Chemical Identifiers

• CAS: 64-86-8
• Molecular Formula: C22H25NO6
• Molecular Weight (g/mol): 399.44
• MDL Number: MFCD00078484,MFCD00078484
• InChI Key: IAKHMKGGTNLKSZ-INIZCTEOSA-N
• Synonym: colchicine, colchicina, colchicin, condylon, colchicinum, colchisol, colsaloid, colcin, colchineos, 7alphah-colchicine
• PubChem CID: 45038708
• IUPAC Name: 2,2,2-trideuterio-N-[(7S)-1,2,3-trimethoxy-9-oxo-10-(trideuteriomethoxy)-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
• SMILES: COC1=C(OC)C(OC)=C2C(CC[C@H](NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1

• Melting Point: 150.0°C to 160.0°C
• Color: Yellow
• Infrared Spectrum: Authentic
• Assay Percent Range: 96% min. on anhydrous and solvent-free substance (HPLC)
• Packaging: Glass bottle
• Quantity: 500 mg
• Beilstein: 14,IV,946
• Merck Index: 15,2455
• Specific Rotation: − 250.00
• Solubility Information: Solubility in water: 45g/l (20°C). Other solubilities: soluble in alcohol and chloroform,practically insoluble in petroleum ether,1g/220mL ether,1g/100mL benzene
• Formula Weight: 399.44
• Percent Purity: 97%
• Physical Form: Powder
• Chemical Name or Material: Colchicine

Safety and Handling

Hazard Category	GHS Signal Word: Danger
Hazard Statement	GHS H Statement: Fatal if swallowed. May cause genetic defects.
Precautionary Statement	GHS P Statement: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. Obtain special instructions before use. IF exposed or concerned: Get medical advice/attention. WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
EINECSNumber	200-598-5

SDS

RUO – Research Use Only