Colchicine, 98%

Catalog No.	Quantity
AAJ6107203	1 g
AAJ61072ME	500 mg
AAJ6107206	5 g

Catalog No. AAJ6107203 Supplier Thermo Scientific Chemicals Supplier No. J6107203

Description

Microtubule disrupting agent, and induces apoptosis in human lymphoma cells | CAS: 64-86-8 | C22H25NO6 | 399.44 g/mol

Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Solubility
Soluble in ethanol (10 mg/ml), water (45 g/L), chloroform, DMSO and methanol.

Notes
Light sensitive. Incompatible with oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 64-86-8
• Molecular Formula: C22H25NO6
• Molecular Weight (g/mol): 399.44
• MDL Number: MFCD00078484,MFCD00078484
• InChI Key: IAKHMKGGTNLKSZ-INIZCTEOSA-N
• Synonym: colchicine, colchicina, colchicin, condylon, colchicinum, colchisol, colsaloid, colcin, colchineos, 7alphah-colchicine
• PubChem CID: 45038708
• IUPAC Name: 2,2,2-trideuterio-N-[(7S)-1,2,3-trimethoxy-9-oxo-10-(trideuteriomethoxy)-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
• SMILES: COC1=C(OC)C(OC)=C2C(CC[C@H](NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1

• Melting Point: ∽150°C (decomposition)
• Color: White to Yellow
• Quantity: 1 g
• UN Number: UN1544
• Beilstein: 2228813
• Sensitivity: Light sensitive
• Merck Index: 14,2471
• Solubility Information: Soluble in ethanol (10mg/ml),water (45g/L),chloroform,DMSO and methanol.
• Formula Weight: 399.44
• Percent Purity: 98%
• Physical Form: Powder
• Chemical Name or Material: Colchicine

Safety and Handling

Hazard Category	H300-H340
Hazard Statement	GHS H Statement H300-H340 Fatal if swallowed. May cause genetic defects.
Precautionary Statement	P201-P202-P264b-P270-P281-P301+P310-P308+P313-P330-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: I; Proper Shipping Name: ALKALOIDS, SOLID, N.O.S.
EINECSNumber	200-598-5
RTECSNumber	GH0700000
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only