Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Unclassified Organic Compounds
  6. Colchicine, 98%, Thermo Scientific Chemicals

Colchicine, 98%, Thermo Scientific Chemicals

Catalog Number AAJ61072ME
Click to view available options
Quantity:
500 mg
1 g
5 g
64-86-8
C22H25NO6
399.44
MFCD00078484,MFCD00078484
IAKHMKGGTNLKSZ-INIZCTEOSA-N
colchicine, colchicina, colchicin, condylon, colchicinum, colchisol, colsaloid, colcin, colchineos, 7alphah-colchicine
45038708
2,2,2-trideuterio-N-[(7S)-1,2,3-trimethoxy-9-oxo-10-(trideuteriomethoxy)-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
COC1=C(OC)C(OC)=C2C(CC[C@H](NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1
64-86-8
C22H25NO6
399.44
MFCD00078484,MFCD00078484
IAKHMKGGTNLKSZ-INIZCTEOSA-N
colchicine, colchicina, colchicin, condylon, colchicinum, colchisol, colsaloid, colcin, colchineos, 7alphah-colchicine
45038708
2,2,2-trideuterio-N-[(7S)-1,2,3-trimethoxy-9-oxo-10-(trideuteriomethoxy)-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
COC1=C(OC)C(OC)=C2C(CC[C@H](NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1

Description

Microtubule disrupting agent, and induces apoptosis in human lymphoma cells

Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Solubility
Soluble in ethanol (10 mg/ml), water (45 g/L), chloroform, DMSO and methanol.

Notes
Light sensitive. Incompatible with oxidizing agents.
TRUSTED_SUSTAINABILITY
Melting Point ∽150°C (decomposition)
Color White to Yellow
Quantity 500 mg
UN Number UN1544
Beilstein 2228813
Sensitivity Light sensitive
Merck Index 14,2471
Solubility Information Soluble in ethanol (10mg/ml),water (45g/L),chloroform,DMSO and methanol.
Formula Weight 399.44
Percent Purity 98%
Physical Form Powder
Chemical Name or Material Colchicine
Show More Show Less

Safety and Handling

Hazard Category H300-H340
Hazard Statement GHS H Statement
H300-H340
Fatal if swallowed.
May cause genetic defects.
Precautionary Statement P201-P202-P264b-P270-P281-P301+P310-P308+P313-P330-P501c
DOTInformation Transport Hazard Class: 6.1; Packing Group: I; Proper Shipping Name: ALKALOIDS, SOLID, N.O.S.
EINECSNumber 200-598-5
RTECSNumber GH0700000
TSCA Yes
Recommended Storage Ambient temperatures
SDS

RUO – Research Use Only

Provide Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit