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AdipoGen Colistin sulfate USP Grade
Supplier: AdipoGen AGCN20065M100
Chemical. CAS 1264-72-8. Formula 2C52H98N16O13 . 5H2SO4 unspec.. MW 2801.7. Isolated from Bacillus polymyxa. Very potent polymyxin antibiotic. Has only one amino acid difference compared to polymyxin B. Antimicrobial. Targets the lipopolysaccharide LPS of the outer membrane of Gram-negative bacteria. Competitively displaces divalent cations Ca2 and Mg2 from the negatively-charged phosphate groups LPS, causing disruption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, leading to apoptosis and cell death. Used against multidrug-resistant Gram-negative bacterial infections.
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