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Medchemexpress LLC Colivelin TFA | 2803948-60-7 | 99.8% | 2759.12 | 5 MG
Supplier: Medchemexpress LLC HYP1061A5MG
Colivelin TFA is a brain-penetrant neuroprotective peptide and a potent activator of STAT3. It suppresses neuronal death in vitro and offers long-term benefits against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. It has potential for treating Alzheimer's disease and ischemic brain injury.
- Suppresses neuronal death and activates neuroprotection through Ca2+/calmodulin-dependent protein kinase IV and STAT3 pathways.
- Reverses caspase3, Bax, and Bcl-2 expressions.
- Increases p-STAT3 protein levels.
- Suppresses spatial working memory impairment and antagonizes hippocampal neuronal loss.
- Improves motor/cognitive function and reduces lesion volume/neurological deficits post-MCAO.
- Protects against cholinotoxin-induced amnesia and ischemic brain injury.
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