3HELIX B-CHP (Collagen Hybridizing Peptide, Biotin Conjugate, 300ug) (BIO300)

Supplier:  3HELIX BIO300

The Collagen Hybridizing Peptide (CHP) is a novel probe that specifically targets damaged collagen in vitro and in vivo. By mimicking the Gly-X-Y repeating sequence, it hybridizes with denatured collagen chains to reform the triple helix. This mechanism provides exceptional specificity with minimal non-specific binding. As a powerful histopathology tool, CHP enables straightforward detection of collagen degradation across a wide range of applications. It can be used to visualize tissue damage from inflammation, disease, or aging; track pericellular matrix turnover during cancer cell migration; measure molecular-level mechanical injury; assess collagen in decellularized matrices; and detect collagen bands on SDS-PAGE gels without Western blotting. B-CHP is labeled with biotin for avidin/streptavidin-mediated detection. B-CHP offers flexible detection options, such as non-green fluorescence and HRP-enzyme methods, to avoid background and enhance signal.

Catalog No. NC3802726