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AdipoGen Collinolactone
SDP

Supplier:  AdipoGen BVT0480C250

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Chemical. CAS 2733581-46-7. Formula C21H28O5. MW 360.45. Collinolactone has neuroprotective and anti-neurodegenerative effects by reducing intracellular oxidative stress. It protects against glutamate-induced oxidative stress in a dose-dependent manner. Collinolactone is a potential anti-Alzheimer agent with Aβ-disaggregating activity. It showed dissociative effect on Aβ aggregates and tau tangles in vitro, with significantly reduced apoptosis and inflammation in neuronal and glial cells. In vivo studies on APP/PS1 double transgenic mice showed substantially dissociated hippocampal plaques. A set of semisynthetic collinolactone analogs but not collinolactone has shown inhibitory effects on a L929 cell line.

Catalog No. 50-256-1878


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