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Medchemexpress LLC Complement C5-IN-1 | 2365402-67-9 | 99.14% | 50 MG
Supplier: Medchemexpress LLC HY12834250MG
Complement C5-IN-1 is a selective allosteric inhibitor of complement component protein C5. It inhibits the cleavage of C5 into C5a and C5b, blocking the formation of the membrane attack complex (MAC). This compound demonstrates an IC50 of 0.77 μM in 50% human whole blood and 5 nM in 2% human serum for blocking MAC deposition induced by zymosan. It is valuable for studying diseases associated with complement overactivation, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). This product is for research use only.
- Selective allosteric inhibitor of complement component protein C5
- Prevents C5 from being cleaved by C5 convertase
- Inhibits cleavage of C5 into C5a and C5b
- Blocks the formation of the membrane attack complex (MAC)
- Supports research into complement overactivation diseases
- Appears as a solid, white to off-white material
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