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Cayman Chemical ComplnatusIde 50mg

Supplier: Cayman Chemical 2729550 MG

A DHODH inhibitor (IC50 20 nM) selective for DHODH over a panel of greater than 400 kinases at 100 nM induces differentiation of ER-HoxA9 U937 and THP-1 cells in vitro (ED50s 1 UM) induces differentiation of tumor cells and reduces tumor growth in a THP-1 mouse xenograft model at 15 mg/kg three times daily or 5 mg/kg per day induces differentiation of bone marrow leukemic cells and increases survival In a retroviral transduction mouse model of HoxA9 Meis1 AML
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