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Cayman Chemical Compound 401 10mg
Supplier: Cayman Chemical 2176910 MG
A dual inhibitor of mTOR and DNA-PK (IC50s = 0.28 and 5.3 µM, respectively); selective for DNA-PK and mTOR over PI3K, ATM, and ATR (IC50s = >100 µM for all); inhibits phosphorylation of the mTOR targets S6K1 and Akt in Rat-1 fibroblasts and in M059J glioma cells that lack DNA-PK at 10 µM; inhibits proliferation of TSC1-/- MEFs (IC50 = 2 µM) but not TSC1+/+ MEFs; induces apoptosis in TSC1-/- MEFs
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