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Medchemexpress LLC Compound 48/80 trihydrochloride | 848035-21-2 | 1 ML
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Supplier:  Medchemexpress LLC HY13059210MM/1ML

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Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. It acts as a histamine releaser and a mast cell degranulator. This compound inhibits phosphatidylinositol-specific phospholipase C activity from human platelets, with IC50 values of 2.1 μg/ml (supernatant) and 5.0 μg/ml (particulate fraction). It also inhibits the aggregation of human platelets induced by ADP and PAF-acether.

  • Acts as a histamine releaser and mast cell degranulator.
  • Inhibits phosphatidylinositol-specific phospholipase C activity.
  • Inhibits human platelet aggregation induced by ADP and PAF-acether.
  • Increases serum serotonin, histamine, and corticosterone levels in vivo.
  • Causes oxidative stress in rat adrenal glands through mast cell degranulation.

Catalog No. 50-003-40734


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