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Apexbio Technology LLC Compound 56 171745-13-4 5mg
Supplier: Apexbio Technology LLC A81975
Compound 56 (CAS 171745-13-4) known as 4-[(3-bromophenyl)amino]-6 7-diethoxyquinazoline is a highly potent and selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase with an IC50 of 0 006 nM It competitively binds to the ATP-binding site of EGFR blocking EGF-dependent receptor phosphorylation Compound 56 suppresses proliferation and colony formation in human cancer cell lines that overexpress EGFR and inhibits EGF-mediated mitogenesis and oncogenic transformation in fibroblasts with EGFR overexpression It also shows moderate inhibition of HER2/neu tyrosine kinase This compound is widely used to investigate EGFR signaling and function in cancer research
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